Lakshmi Rajagopal Selected Research

Phencyclidine (Angel Dust)

1/2022	Repeated administration of rapastinel produces exceptionally prolonged rescue of memory deficits in phencyclidine-treated mice.
1/2020	Effects of NBI-98782, a selective vesicular monoamine transporter 2 (VMAT2) inhibitor, on neurotransmitter efflux and phencyclidine-induced locomotor activity: Relevance to tardive dyskinesia and antipsychotic action.
1/2019	The allosteric dopamine D1 receptor potentiator, DETQ, ameliorates subchronic phencyclidine-induced object recognition memory deficits and enhances cortical acetylcholine efflux in male humanized D1 receptor knock-in mice.
11/2018	TPA-023 attenuates subchronic phencyclidine-induced declarative and reversal learning deficits via GABAA receptor agonist mechanism: possible therapeutic target for cognitive deficit in schizophrenia.
2/2016	GLYX-13 (rapastinel) ameliorates subchronic phencyclidine- and ketamine-induced declarative memory deficits in mice.
2/2016	Serotonin (5-HT)1A receptor agonism and 5-HT7 receptor antagonism ameliorate the subchronic phencyclidine-induced deficit in executive functioning in mice.
11/2015	Dopamine D3 receptor antagonism contributes to blonanserin-induced cortical dopamine and acetylcholine efflux and cognitive improvement.
5/2015	Combined serotonin (5-HT)1A agonism, 5-HT(2A) and dopamine D₂ receptor antagonism reproduces atypical antipsychotic drug effects on phencyclidine-impaired novel object recognition in rats.
11/2013	Translating the N-methyl-D-aspartate receptor antagonist model of schizophrenia to treatments for cognitive impairment in schizophrenia.
12/2010	Animal models of cognitive dysfunction and negative symptoms of schizophrenia: focus on NMDA receptor antagonism.

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Lakshmi Rajagopal Research Topics

Disease

26	Infections 12/2022 - 06/2007
11	Cognitive Dysfunction 01/2021 - 12/2010
11	Schizophrenia (Dementia Praecox) 01/2021 - 12/2010
8	Premature Obstetric Labor (Premature Labor) 01/2021 - 12/2015
6	Premature Birth (Birth, Premature) 01/2021 - 04/2015
5	Inflammation (Inflammations) 01/2021 - 06/2010
4	Bacterial Infections (Bacterial Infection) 10/2020 - 03/2009
3	Memory Disorders (Memory Loss) 01/2022 - 02/2016
3	Stillbirth 01/2021 - 11/2017
3	Streptococcal Infections (Streptococcal Infection) 10/2020 - 03/2014
3	Hemolysis 01/2020 - 04/2015
2	Lung Injury 01/2021 - 10/2015
2	fetal inflammatory response syndrome 01/2021 - 01/2018
2	Psychotic Disorders (Schizoaffective Disorder) 11/2018 - 01/2017
2	Sepsis (Septicemia) 09/2006 - 11/2003
1	Acquired Immunodeficiency Syndrome (AIDS) 10/2021
1	Bronchopulmonary Dysplasia 01/2021
1	Bacteremia 01/2021
1	Communicable Diseases (Infectious Diseases) 01/2021
1	Teratogenesis 01/2021
1	Spontaneous Abortion (Miscarriage) 01/2021
1	Preterm Premature Rupture of the Membranes 10/2020
1	Tardive Dyskinesia 01/2020
1	Chorioamnionitis 01/2020
1	Pneumonia (Pneumonitis) 01/2020
1	Brain Injuries (Brain Injury) 12/2019
1	Microcephaly 10/2019
1	Bacterial Vaginosis 08/2019
1	Zika Virus Infection 01/2018
1	Neoplasms (Cancer) 01/2017
1	Fetal Death 01/2016
1	Polyhydramnios 12/2015
1	Lung Diseases (Lung Disease) 10/2015

Drug/Important Bio-Agent (IBA)

10	Phencyclidine (Angel Dust)IBA 01/2022 - 12/2010
6	Virulence Factors (Pathogenicity Factors)IBA 10/2021 - 12/2012
6	CytokinesIBA 01/2021 - 07/2013
6	Antipsychotic Agents (Antipsychotics)IBA 01/2020 - 12/2010
5	Interleukin-6 (Interleukin 6)IBA 01/2021 - 06/2010
4	VaccinesIBA 12/2022 - 11/2017
4	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2022 - 12/2010
4	LipidsIBA 01/2020 - 01/2015
3	AntibodiesIBA 12/2022 - 10/2019
3	Anti-Bacterial Agents (Antibiotics)IBA 01/2021 - 01/2018
3	Hyaluronoglucosaminidase (Hyaluronidase)FDA Link 01/2021 - 01/2016
3	Acetylcholine (Acetylcholine Chloride)FDA Link 01/2019 - 11/2015
3	Phosphotransferases (Kinase)IBA 01/2018 - 12/2011
3	Ketamine FDA LinkGeneric 02/2016 - 12/2010
3	Serine (L-Serine)FDA Link 12/2011 - 09/2006
3	Threonine (L-Threonine)FDA Link 12/2011 - 09/2006
2	GLYX-13 peptideIBA 01/2022 - 02/2016
2	Antidepressive Agents (Antidepressants)IBA 01/2022 - 02/2016
2	ProstaglandinsIBA 01/2021 - 12/2015
2	Interleukin-8 (Interleukin 8)IBA 01/2021 - 12/2015
2	Pharmaceutical PreparationsIBA 01/2021 - 03/2009
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2021 - 12/2015
2	MicroRNAs (MicroRNA)IBA 10/2020 - 10/2015
2	Neurotransmitter Agents (Neurotransmitter)IBA 01/2020 - 03/2014
2	Dopamine (Intropin)FDA LinkGeneric 01/2019 - 10/2018
2	Biomarkers (Surrogate Marker)IBA 01/2018 - 01/2017
2	Proteins (Proteins, Gene)FDA Link 10/2015 - 09/2006
2	Dizocilpine Maleate (Dizocilpine)IBA 11/2013 - 12/2010
2	Phosphoric Monoester Hydrolases (Phosphatases)IBA 12/2011 - 07/2011
2	Hemolysin Proteins (Hemolysins)IBA 12/2011 - 06/2010
1	Protein Subunits (Protein Subunit)IBA 12/2022
1	Capsules (Microcapsules)IBA 10/2021
1	Matrix Metalloproteinases (MMPs)IBA 01/2021
1	Bumetanide (Bumex)FDA LinkGeneric 01/2021
1	EnzymesIBA 01/2021
1	Interleukin-1beta (Interleukin 1 beta)IBA 01/2021
1	VimentinIBA 10/2020
1	Cadherins (E-Cadherin)IBA 10/2020
1	valbenazineIBA 01/2020
1	Peroxidase (Myeloperoxidase)IBA 01/2020
1	ChemokinesIBA 01/2020
1	Vesicular Monoamine Transport Proteins (Vesicular Monoamine Transporter)IBA 01/2020
1	Influenza Vaccines (Influenza Vaccine)FDA Link 12/2019
1	Bacterial DNAIBA 08/2019
1	Dopamine D1 Receptors (Dopamine D1 Receptor)IBA 01/2019
1	7- (1,1- dimethylethyl)- 6- (2- ethyl- 2H- 1,2,4- triazol- 3- ylmethoxy)- 3- (2- fluorophenyl)- 1,2,4- triazolo(4,3- b)pyridazineIBA 11/2018
1	Lurasidone Hydrochloride FDA Link 10/2018
1	Glutamic Acid (Glutamate)FDA Link 10/2018
1	Chymases (Chymase)IBA 01/2018
1	Carrier Proteins (Binding Protein)IBA 01/2018
1	Leucine (L-Leucine)FDA Link 01/2018
1	Histidine KinaseIBA 01/2018
1	Tryptophan (L-Tryptophan)FDA Link 01/2018
1	Cytidine Monophosphate (CMP)IBA 01/2018
1	Fibronectins (Fibronectin)IBA 01/2018
1	RP5063IBA 01/2017
1	Messenger RNA (mRNA)IBA 12/2015
1	InterleukinsIBA 12/2015
1	Dinoprostone (PGE2)FDA Link 12/2015
1	Interferon-gamma (Interferon, gamma)IBA 10/2015
1	InflammasomesIBA 04/2015
1	Keratins (Keratin)IBA 03/2014

Therapy/Procedure

10	Therapeutics 01/2022 - 12/2010
1	Prenatal Care (Care, Prenatal) 12/2019
1	Antibiotic Prophylaxis 11/2017
1	Immunotherapy 01/2017
1	Cesarean Section (Caesarean Section) 03/2014